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FDA Commissioner Marty Makary resigned Tuesday after 13 months leading the agency, with HHS Secretary Robert F. Kennedy Jr. playing a central role in the decision. A White House official said Kennedy "made the call," while the resignation came one day before Makary was set to testify before the Senate Appropriations Committee.

FDA Commissioner Marty Makary resigned Tuesday after 13 months leading the agency, with HHS Secretary Robert F. Kennedy Jr. playing a central role in the decision. A White House official said Kennedy "made the call," while the resignation came one day before Makary was set to testify before the Senate Appropriations Committee.

Makary's departure was driven in large part by his resistance to authorizing fruit-flavored e-cigarettes, which Trump had promised to "save" during the 2024 campaign. The FDA reversed course and approved the first fruit-flavored vapes for adults 21 and over shortly before Makary's exit.

Makary's departure was driven in large part by his resistance to authorizing fruit-flavored e-cigarettes, which Trump had promised to "save" during the 2024 campaign. The FDA reversed course and approved the first fruit-flavored vapes for adults 21 and over shortly before Makary's exit.

Anti-abortion groups also pressured the White House to remove Makary, citing his handling of the abortion pill mifepristone. SBA Pro-Life America President Marjorie Dannenfelser called for Makary to be "fired immediately," while Sen. Josh Hawley called him "uniquely destructive to the pro-life movement."

Anti-abortion groups also pressured the White House to remove Makary, citing his handling of the abortion pill mifepristone. SBA Pro-Life America President Marjorie Dannenfelser called for Makary to be "fired immediately," while Sen. Josh Hawley called him "uniquely destructive to the pro-life movement."

Kyle Diamantas, the FDA's top food official and a former corporate lawyer at Jones Day, was named acting commissioner following Makary's exit. Diamantas does not hold a medical degree, a credential that has traditionally been expected of FDA leaders.

Kyle Diamantas, the FDA's top food official and a former corporate lawyer at Jones Day, was named acting commissioner following Makary's exit. Diamantas does not hold a medical degree, a credential that has traditionally been expected of FDA leaders.

Makary's tenure was marked by significant staff losses, with more than 4,000 employees — roughly a fifth of the FDA's workforce — departing through layoffs or voluntary exits. His handpicked deputy, Dr. Vinay Prasad, left the agency twice in under a year amid clashes with drugmakers and patient advocates.

Makary's tenure was marked by significant staff losses, with more than 4,000 employees — roughly a fifth of the FDA's workforce — departing through layoffs or voluntary exits. His handpicked deputy, Dr. Vinay Prasad, left the agency twice in under a year amid clashes with drugmakers and patient advocates.

Makary's resignation marks the fourth high-profile departure from the Trump administration since January, following former Homeland Security Secretary Kristi Noem, former Attorney General Pam Bondi and former Labor Secretary Lori Chavez DeRemer. A permanent FDA commissioner must be nominated by Trump and confirmed by the Senate.

Makary's resignation marks the fourth high-profile departure from the Trump administration since January, following former Homeland Security Secretary Kristi Noem, former Attorney General Pam Bondi and former Labor Secretary Lori Chavez DeRemer. A permanent FDA commissioner must be nominated by Trump and confirmed by the Senate.

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