Dr. Marty Makary is out as FDA commissioner

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Metaculus

Drugs approved by FDA in 2035

U.S. Food and Drug Administration (FDA) Commissioner Marty Makary resigned on Tuesday after 13 months leading the agency. A White House official said that Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. "made this decision," while the resignation came one day before Makary was set to testify before the Senate Appropriations Committee.

U.S. Food and Drug Administration (FDA) Commissioner Marty Makary resigned on Tuesday after 13 months leading the agency. A White House official said that Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. "made this decision," while the resignation came one day before Makary was set to testify before the Senate Appropriations Committee.

Makary's departure was reportedly driven in large part by his resistance to authorizing fruit-flavored e-cigarettes, which President Donald Trump had promised to "save" during the 2024 campaign. The FDA reversed course and <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.verity.news/story/2026/fda-approves-first-flavored-vape-pods-under-trump-push">approved the first fruit-flavored vapes </a>for adults 21 and over shortly before Makary's exit.

Makary's departure was reportedly driven in large part by his resistance to authorizing fruit-flavored e-cigarettes, which President Donald Trump had promised to "save" during the 2024 campaign. The FDA reversed course and approved the first fruit-flavored vapes for adults 21 and over shortly before Makary's exit.

Anti-abortion groups had also pressured the White House to remove Makary, citing his handling of the abortion pill mifepristone.

Anti-abortion groups had also pressured the White House to remove Makary, citing his handling of the abortion pill mifepristone.

Kyle Diamantas, the FDA's top food official and a former corporate lawyer at Jones Day, was named acting commissioner. Diamantas doesn't hold a medical degree, a credential that has traditionally been expected of FDA leaders.

Kyle Diamantas, the FDA's top food official and a former corporate lawyer at Jones Day, was named acting commissioner. Diamantas doesn't hold a medical degree, a credential that has traditionally been expected of FDA leaders.

Makary's tenure was marked by significant staff losses, with more than 4,000 employees — roughly a fifth of the FDA's workforce — departing through layoffs or voluntary exits. His handpicked deputy, Dr. Vinay Prasad, left the agency twice in under a year amid issues with drugmakers and patient advocates.

Makary's tenure was marked by significant staff losses, with more than 4,000 employees — roughly a fifth of the FDA's workforce — departing through layoffs or voluntary exits. His handpicked deputy, Dr. Vinay Prasad, left the agency twice in under a year amid issues with drugmakers and patient advocates.

This is the fourth high-profile departure from the Trump administration since January, following former Homeland Security Secretary Kristi Noem, former Attorney General Pam Bondi and former Labor Secretary Lori Chavez DeRemer. A permanent FDA commissioner must be nominated by Trump and confirmed by the Senate.

This is the fourth high-profile departure from the Trump administration since January, following former Homeland Security Secretary Kristi Noem, former Attorney General Pam Bondi and former Labor Secretary Lori Chavez DeRemer. A permanent FDA commissioner must be nominated by Trump and confirmed by the Senate.

Makary was the rare FDA chief who actually stood up to Big Pharma and Big Food instead of caving to their lobbying. His push to remove outdated safety warnings on menopause treatments and target ultra-processed foods showed real commitment to public health over corporate profits. Forcing him out is a win for special interests and could put women's reproductive rights at risk.

Makary was the rare FDA chief who actually stood up to Big Pharma and Big Food instead of caving to their lobbying. His push to remove outdated safety warnings on menopause treatments and target ultra-processed foods showed real commitment to public health over corporate profits. Forcing him out is a win for special interests and could put women's reproductive rights at risk.

Katie Pavlich

Kelly Ryerson

Narrative A

Makary betrayed voters on numerous issues, especially abortion. He slow-walked a critical safety review of mifepristone for political reasons while publicly claiming progress — a betrayal of the pro-life voters who put this administration in power. The FDA under Makary made things worse, not better. His resignation is a necessary reset.

Makary betrayed voters on numerous issues, especially abortion. He slow-walked a critical safety review of mifepristone for political reasons while publicly claiming progress — a betrayal of the pro-life voters who put this administration in power. The FDA under Makary made things worse, not better. His resignation is a necessary reset.

Gunther Eagleman

Josh Hawley

Narrative B

There's a 50% chance that at least 82 drugs will be approved by the FDA in 2035, according to the Metaculus prediction community.

There's a 50% chance that at least 82 drugs will be approved by the FDA in 2035, according to the Metaculus prediction community.

FDA Chief Marty Makary Resigns

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FDA Chief Marty Makary Resigns

The Spin

Narrative A

Narrative B

Metaculus Prediction

Public Figures

Go Deeper

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