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Kindred Companion Sciences, a biotechnology startup founded in 2020, has published peer-reviewed results in The CRISPR Journal detailing the creation of two gene-edited beagles, Alfie and Bailey, born in September 2024, that lack the primary protein responsible for dog allergies.

Kindred Companion Sciences, a biotechnology startup founded in 2020, has published peer-reviewed results in The CRISPR Journal detailing the creation of two gene-edited beagles, Alfie and Bailey, born in September 2024, that lack the primary protein responsible for dog allergies.

The main allergen in dogs, a protein called Can f 1, is found in saliva and dander and triggers reactions in more than half of people with dog allergies. Tests confirmed Can f 1 was undetectable in Alfie and Bailey's saliva and dander samples.

The main allergen in dogs, a protein called Can f 1, is found in saliva and dander and triggers reactions in more than half of people with dog allergies. Tests confirmed Can f 1 was undetectable in Alfie and Bailey's saliva and dander samples.

To produce the dogs, the Kindred team used CRISPR-Cas9 to introduce a mutation in the Can f 1 gene within beagle skin cells, then cloned those cells and transferred 25 embryos to a surrogate, of which two developed to term.

To produce the dogs, the Kindred team used CRISPR-Cas9 to introduce a mutation in the Can f 1 gene within beagle skin cells, then cloned those cells and transferred 25 embryos to a surrogate, of which two developed to term.

Skin prick tests showed no allergic reaction to samples from Alfie and Bailey, while samples from a poodle and goldendoodle — breeds often considered hypoallergenic — did produce measurable reactions, consistent with findings from the American Academy of Asthma, Allergy and Immunology.

Skin prick tests showed no allergic reaction to samples from Alfie and Bailey, while samples from a poodle and goldendoodle — breeds often considered hypoallergenic — did produce measurable reactions, consistent with findings from the American Academy of Asthma, Allergy and Immunology.

Bioethicist Arthur Caplan of New York University's Grossman School of Medicine noted the development "opens the door to a lot more people being able to own pets" but cautioned it may reduce adoptions of shelter animals. Kindred's dogs are not yet commercially available and require FDA approval.

Bioethicist Arthur Caplan of New York University's Grossman School of Medicine noted the development "opens the door to a lot more people being able to own pets" but cautioned it may reduce adoptions of shelter animals. Kindred's dogs are not yet commercially available and require FDA approval.

Dr. Jeff SoRelle, a pathologist at the University of Texas Southwestern Medical Center, said future research should test the gene-edited dogs on a broader range of people with pet allergies, noting Can f 1 is the primary but not sole allergy-causing protein in dogs.

Dr. Jeff SoRelle, a pathologist at the University of Texas Southwestern Medical Center, said future research should test the gene-edited dogs on a broader range of people with pet allergies, noting Can f 1 is the primary but not sole allergy-causing protein in dogs.

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