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Weight loss drugs linked to loss of hair in major new study

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A study published in The BMJ found that GLP-1 receptor agonist drugs — including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) — were associated with a 37% higher risk of alopecia than SGLT-2 inhibitors and a 68% higher risk than DPP-4 inhibitors.

A study published in The BMJ found that GLP-1 receptor agonist drugs — including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) — were associated with a 37% higher risk of alopecia than SGLT-2 inhibitors and a 68% higher risk than DPP-4 inhibitors.

The study, led by researchers at the University of Pennsylvania, used electronic health records from January 2019 to September 2024, comparing 12,004 GLP-1 drug users with 15,221 SGLT-2 inhibitor users and 11,964 GLP-1 users with 11,233 DPP-4 inhibitor users.

The study, led by researchers at the University of Pennsylvania, used electronic health records from January 2019 to September 2024, comparing 12,004 GLP-1 drug users with 15,221 SGLT-2 inhibitor users and 11,964 GLP-1 users with 11,233 DPP-4 inhibitor users.

The elevated hair loss risk was specific to non-scarring alopecia, where hair follicles remain intact and regrowth is possible, with GLP-1 users showing a 53% and 72% higher risk compared with SGLT-2 and DPP-4 inhibitor users, respectively.

The elevated hair loss risk was specific to non-scarring alopecia, where hair follicles remain intact and regrowth is possible, with GLP-1 users showing a 53% and 72% higher risk compared with SGLT-2 and DPP-4 inhibitor users, respectively.

Researchers said the most likely mechanism behind hair loss in GLP-1 users relates to weight loss and reduced caloric intake, which may cause micronutrient deficiencies — such as iron, zinc and biotin — that disrupt the hair growth cycle.

Researchers said the most likely mechanism behind hair loss in GLP-1 users relates to weight loss and reduced caloric intake, which may cause micronutrient deficiencies — such as iron, zinc and biotin — that disrupt the hair growth cycle.

The absolute rate of alopecia among GLP-1 users was low, ranging from roughly 3 to 9 per 1,000 people per year. Researchers noted the findings may still influence patients' decisions to start or continue therapy.

The absolute rate of alopecia among GLP-1 users was low, ranging from roughly 3 to 9 per 1,000 people per year. Researchers noted the findings may still influence patients' decisions to start or continue therapy.

The UK's Medicines and Healthcare products Regulatory Agency had received 399 reports of hair loss linked to tirzepatide in 2026 so far, alongside 541 in the prior year, and 148 reports tied to semaglutide, alongside 164 the year before.

The UK's Medicines and Healthcare products Regulatory Agency had received 399 reports of hair loss linked to tirzepatide in 2026 so far, alongside 541 in the prior year, and 148 reports tied to semaglutide, alongside 164 the year before.

Weight loss drugs linked to loss of hair in major new study

Weight loss drugs linked to loss of hair in major new study

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