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A Cochrane review of 17 clinical trials involving more than 20,000 people found that anti-amyloid drugs for Alzheimer's disease had effects on cognitive decline and dementia severity that were "absent or trivial" and fell below thresholds for minimum clinically important difference.

A Cochrane review of 17 clinical trials involving more than 20,000 people found that anti-amyloid drugs for Alzheimer's disease had effects on cognitive decline and dementia severity that were "absent or trivial" and fell below thresholds for minimum clinically important difference.

The review examined seven anti-amyloid drugs, including lecanemab, sold as Leqembi by Biogen and Eisai, and donanemab, sold as Kisunla by Eli Lilly. Both drugs were approved by the U.S. and European Union but have been declined by state-run health services in the UK and France.

The review examined seven anti-amyloid drugs, including lecanemab, sold as Leqembi by Biogen and Eisai, and donanemab, sold as Kisunla by Eli Lilly. Both drugs were approved by the U.S. and European Union but have been declined by state-run health services in the UK and France.

The Cochrane review found that anti-amyloid drugs likely increase the risk of brain swelling and bleeding. Patients receiving the treatments must also visit a clinic every two to four weeks for intravenous infusions and regular MRI scans.

The Cochrane review found that anti-amyloid drugs likely increase the risk of brain swelling and bleeding. Patients receiving the treatments must also visit a clinic every two to four weeks for intravenous infusions and regular MRI scans.

Lead study author Francesco Nonino of Italy's IRCCS Institute said early trials showed statistically significant results but that it is "common for trials to find statistically significant results that do not translate into a meaningful clinical difference for patients."

Lead study author Francesco Nonino of Italy's IRCCS Institute said early trials showed statistically significant results but that it is "common for trials to find statistically significant results that do not translate into a meaningful clinical difference for patients."

Critics of the review, including Prof. Bart De Strooper of the UK Dementia Research Institute at UCL, argued the analysis "blurs" rather than clarifies evidence by combining older, failed drugs with newer treatments shown to deliver "modest yet real clinical benefit."

Daily Mail

Critics of the review, including Prof. Bart De Strooper of the UK Dementia Research Institute at UCL, argued the analysis "blurs" rather than clarifies evidence by combining older, failed drugs with newer treatments shown to deliver "modest yet real clinical benefit."

The Cochrane review's methodology involved pooling data across different anti-amyloid drugs on the basis that all share a similar mechanism of action by targeting amyloid-beta proteins. The most recent search date for included studies was Aug. 7, 2025.

The Cochrane review's methodology involved pooling data across different anti-amyloid drugs on the basis that all share a similar mechanism of action by targeting amyloid-beta proteins. The most recent search date for included studies was Aug. 7, 2025.

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Effect of ‘gamechanger’ Alzheimer’s drugs ‘trivial’, review concludes

Alzheimer's Drugs Show 'Trivial' Benefits, Review Finds

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Alzheimer's Drugs Show 'Trivial' Benefits, Review Finds

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