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A man kept alive for 48 hours without lungs thanks to an artificial organ before a transplant

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A 33-year-old man survived for 48 hours without lungs after surgeons at Northwestern University removed his infected organs and connected him to an artificial lung system. The patient had developed acute respiratory distress syndrome triggered by influenza B and a drug-resistant bacterial infection.

Hashem Al-Ghaili

A 33-year-old man survived for 48 hours without lungs after surgeons at Northwestern University removed his infected organs and connected him to an artificial lung system. The patient had developed acute respiratory distress syndrome triggered by influenza B and a drug-resistant bacterial infection.

Dr. Ankit Bharat and his team at Northwestern University Feinberg School of Medicine designed a flow-adaptive extracorporeal total artificial lung system that maintained balanced blood flow through the heart. The system included a dual-lumen cannula, a flow-adaptive shunt, and dual left atrial returns.

Dr. Ankit Bharat and his team at Northwestern University Feinberg School of Medicine designed a flow-adaptive extracorporeal total artificial lung system that maintained balanced blood flow through the heart. The system included a dual-lumen cannula, a flow-adaptive shunt, and dual left atrial returns.

The patient's condition improved rapidly after the infected lungs were removed, with blood pressure stabilizing and organ function recovering within hours. His lactate levels dropped from 8.2 mmol/L to less than 1.0 mmol/L within 24 hours, and medications to support blood pressure were discontinued after 12 hours.

The patient's condition improved rapidly after the infected lungs were removed, with blood pressure stabilizing and organ function recovering within hours. His lactate levels dropped from 8.2 mmol/L to less than 1.0 mmol/L within 24 hours, and medications to support blood pressure were discontinued after 12 hours.

Molecular analysis of the removed lungs revealed extensive scarring, immune damage and nearly complete loss of stem cells required to rebuild lung tissue. The findings showed the lungs had reached an irreversible stage and could not recover on their own despite life support.

Molecular analysis of the removed lungs revealed extensive scarring, immune damage and nearly complete loss of stem cells required to rebuild lung tissue. The findings showed the lungs had reached an irreversible stage and could not recover on their own despite life support.

Donor lungs became available 48 hours after the bilateral pneumonectomy, and surgeons successfully performed a double lung transplant. The patient's heart had stopped upon hospital arrival and required CPR before the groundbreaking procedure could be attempted.

Donor lungs became available 48 hours after the bilateral pneumonectomy, and surgeons successfully performed a double lung transplant. The patient's heart had stopped upon hospital arrival and required CPR before the groundbreaking procedure could be attempted.

More than two years after the procedure, the patient has returned to daily life with excellent lung function and no signs of organ rejection. Researchers say the findings, published Friday in the journal Med, establish a potential blueprint for saving critically ill patients previously considered beyond hope.

More than two years after the procedure, the patient has returned to daily life with excellent lung function and no signs of organ rejection. Researchers say the findings, published Friday in the journal Med, establish a potential blueprint for saving critically ill patients previously considered beyond hope.

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More than two years after the procedure, the patient has returned to daily life with excellent lung function and no signs of organ rejection. Researchers say the findings, published last week in the journal Med, establish a potential blueprint for saving critically ill patients previously considered beyond hope.

More than two years after the procedure, the patient has returned to daily life with excellent lung function and no signs of organ rejection. Researchers say the findings, published last week in the journal Med, establish a potential blueprint for saving critically ill patients previously considered beyond hope.

Removing infected lungs and using artificial systems as a bridge to transplant saves lives that would otherwise be lost. Molecular evidence proves some ARDS patients have irreversible lung damage and will die without transplantation, yet young patients die weekly because transplant isn't considered an option. This breakthrough demonstrates that acute lung failure from infections can be treated with transplantation when conventional support fails.

Removing infected lungs and using artificial systems as a bridge to transplant saves lives that would otherwise be lost. Molecular evidence proves some ARDS patients have irreversible lung damage and will die without transplantation, yet young patients die weekly because transplant isn't considered an option. This breakthrough demonstrates that acute lung failure from infections can be treated with transplantation when conventional support fails.

The external artificial lung system represents a major technical achievement that transforms hopeless cases into viable treatment pathways. This device maintains normal cardiac function without lungs, something previously considered virtually impossible, and allows critically ill patients to stabilize before transplant. The patient's spectacular recovery and excellent quality of life three years later proves this approach works.

The external artificial lung system represents a major technical achievement that transforms hopeless cases into viable treatment pathways. This device maintains normal cardiac function without lungs, something previously considered virtually impossible, and allows critically ill patients to stabilize before transplant. The patient's spectacular recovery and excellent quality of life three years later proves this approach works.

Man Survives 48 Hours Without Lungs Using Artificial System

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The external artificial lung system is a major technical achievement that transforms hopeless cases into viable treatment pathways. This device maintains normal cardiac function without lungs, something previously considered virtually impossible, and allows critically ill patients to stabilize before transplant. The patient's spectacular recovery and excellent quality of life three years later prove this approach works.

The external artificial lung system is a major technical achievement that transforms hopeless cases into viable treatment pathways. This device maintains normal cardiac function without lungs, something previously considered virtually impossible, and allows critically ill patients to stabilize before transplant. The patient's spectacular recovery and excellent quality of life three years later prove this approach works.

Surviving without lungs for two days highlights both ingenuity and the limits of modern medicine. Though an artificial lung system kept him alive, this technique is complex, risky and currently available only at elite centers. Its rarity and resource intensity raise ethical questions about widespread use, cost and patient selection before it becomes a standard option.

Surviving without lungs for two days highlights both ingenuity and the limits of modern medicine. Though an artificial lung system kept him alive, this technique is complex, risky and currently available only at elite centers. Its rarity and resource intensity raise ethical questions about widespread use, cost and patient selection before it becomes a standard option.

There's a 75% chance that lab-grown complex vital organs will be used successfully in humans before 2035, according to the Metaculus prediction community.

There's a 75% chance that lab-grown complex vital organs will be used successfully in humans before 2035, according to the Metaculus prediction community.

Man Survives 48 Hours Without Lungs Using Artificial System

Man Survives 48 Hours Without Lungs Using Artificial System

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Man Survives 48 Hours Without Lungs Using Artificial System

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