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A 33-year-old man survived for 48 hours without lungs after surgeons at Northwestern University removed his infected organs and connected him to an artificial lung system. The patient had developed acute respiratory distress syndrome triggered by influenza B and a drug-resistant bacterial infection.

A 33-year-old man survived for 48 hours without lungs after surgeons at Northwestern University removed his infected organs and connected him to an artificial lung system. The patient had developed acute respiratory distress syndrome triggered by influenza B and a drug-resistant bacterial infection.

Dr. Ankit Bharat and his team at Northwestern University Feinberg School of Medicine designed a flow-adaptive extracorporeal total artificial lung system that maintained balanced blood flow through the heart. The system included a dual-lumen cannula, flow-adaptive shunt and dual left atrial return.

Dr. Ankit Bharat and his team at Northwestern University Feinberg School of Medicine designed a flow-adaptive extracorporeal total artificial lung system that maintained balanced blood flow through the heart. The system included a dual-lumen cannula, flow-adaptive shunt and dual left atrial return.

The patient's condition improved rapidly after the infected lungs were removed, with blood pressure stabilizing and organ function recovering within hours. His lactate levels dropped from 8.2 mmol/L to less than 1.0 mmol/L within 24 hours, and medications to support blood pressure were discontinued after 12 hours.

The patient's condition improved rapidly after the infected lungs were removed, with blood pressure stabilizing and organ function recovering within hours. His lactate levels dropped from 8.2 mmol/L to less than 1.0 mmol/L within 24 hours, and medications to support blood pressure were discontinued after 12 hours.

Molecular analysis of the removed lungs revealed extensive scarring, immune damage and nearly complete loss of stem cells required to rebuild lung tissue. The findings showed the lungs had reached an irreversible stage and could not recover on their own despite life support.

Molecular analysis of the removed lungs revealed extensive scarring, immune damage and nearly complete loss of stem cells required to rebuild lung tissue. The findings showed the lungs had reached an irreversible stage and could not recover on their own despite life support.

Donor lungs became available 48 hours after the bilateral pneumonectomy, and surgeons successfully performed a double lung transplant. The patient's heart had stopped upon hospital arrival and required CPR before the groundbreaking procedure could be attempted.

Donor lungs became available 48 hours after the bilateral pneumonectomy, and surgeons successfully performed a double lung transplant. The patient's heart had stopped upon hospital arrival and required CPR before the groundbreaking procedure could be attempted.

More than two years after the procedure, the patient has returned to daily life with excellent lung function and no signs of organ rejection. The findings were published in the journal Med in January 2025, establishing a potential blueprint for saving critically ill patients previously considered beyond hope.

More than two years after the procedure, the patient has returned to daily life with excellent lung function and no signs of organ rejection. The findings were published in the journal Med in January 2025, establishing a potential blueprint for saving critically ill patients previously considered beyond hope.

Man Survives 48 Hours Without Lungs Using Artificial System

Man Survives 48 Hours Without Lungs Using Artificial System

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Man Survives 48 Hours Without Lungs Using Artificial System

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