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New research by the University of Cambridge has revealed a link between the menopause and a loss of gray matter in the brain, highlighting a possible connection between the condition and the development of Alzheimer's later in life.

New research by the University of Cambridge has revealed a link between the menopause and a loss of gray matter in the brain, highlighting a possible connection between the condition and the development of Alzheimer's later in life.

The study, which involved nearly 125,000 women, found that areas within the brain associated with memory, emotion and attention — namely the hippocampus, entorhinal cortex and anterior cingulate cortex — decreased in volume following menopause.

The study, which involved nearly 125,000 women, found that areas within the brain associated with memory, emotion and attention — namely the hippocampus, entorhinal cortex and anterior cingulate cortex — decreased in volume following menopause.

Hormone replacement therapy (HRT), however, was not found to prevent gray matter loss in post-menopausal women, though those treated with HRT demonstrated slightly faster reaction times compared to those who were not.

Hormone replacement therapy (HRT), however, was not found to prevent gray matter loss in post-menopausal women, though those treated with HRT demonstrated slightly faster reaction times compared to those who were not.

Separately, post-menopausal women reported higher levels of anxiety, depression, insomnia and tiredness compared to their pre-menopausal counterparts, with the highest levels of anxiety, depression and tiredness found in the HRT study group.

Separately, post-menopausal women reported higher levels of anxiety, depression, insomnia and tiredness compared to their pre-menopausal counterparts, with the highest levels of anxiety, depression and tiredness found in the HRT study group.

The study population was drawn from the U.K. Biobank, a cohort of 502,486 men and women recruited in the U.K. between 2006 and 2010. Within this research group, the average age for menopause onset was recorded at 49.5 years, while the average age for beginning HRT treatment was 49 years.

The study population was drawn from the U.K. Biobank, a cohort of 502,486 men and women recruited in the U.K. between 2006 and 2010. Within this research group, the average age for menopause onset was recorded at 49.5 years, while the average age for beginning HRT treatment was 49 years.

Commenting on the results, the researchers said that their findings may help explain why women, who account for two-thirds of those with Alzheimer's in the U.K., are reportedly more vulnerable to the disease, while emphasizing that a healthy lifestyle may mitigate the effects of menopause.

Commenting on the results, the researchers said that their findings may help explain why women, who account for two-thirds of those with Alzheimer's in the U.K., are reportedly more vulnerable to the disease, while emphasizing that a healthy lifestyle may mitigate the effects of menopause.

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New research by the University of Cambridge has revealed a link between the menopause and a loss of grey matter in the brain, highlighting a possible connection between the condition and the development of Alzheimer's later in life.

New research by the University of Cambridge has revealed a link between the menopause and a loss of grey matter in the brain, highlighting a possible connection between the condition and the development of Alzheimer's later in life.

Hormone replacement therapy (HRT), however, was not found to prevent grey matter loss in post-menopausal women, though those treated with HRT demonstrated slightly faster reaction times compared to those who were not.

Hormone replacement therapy (HRT), however, was not found to prevent grey matter loss in post-menopausal women, though those treated with HRT demonstrated slightly faster reaction times compared to those who were not.

Commenting on the results, the researchers said that their findings may help explain why women, who account for two-thirds of those with Alzheimer's in the U.K., are more vulnerable to the disease, while emphasizing that a healthy lifestyle may mitigate the effects of menopause.

Commenting on the results, the researchers said that their findings may help explain why women, who account for two-thirds of those with Alzheimer's in the U.K., are more vulnerable to the disease, while emphasizing that a healthy lifestyle may mitigate the effects of menopause.

HRT could prove vital in the fight against Alzheimer's in women. As research has shown, starting the treatment within five years of menopause can reduce the risk of Alzheimer's by as much as 32%, with observational studies showing a 22% lower dementia risk for all HRT users. Timing, therefore, is crucial, with early intervention offering the best chance of protecting brain function.

HRT could prove vital in the fight against Alzheimer's in women. As research has shown, starting the treatment within five years of menopause can reduce the risk of Alzheimer's by as much as 32%, with observational studies showing a 22% lower dementia risk for all HRT users. Timing, therefore, is crucial, with early intervention offering the best chance of protecting brain function.

It is evident from the University of Cambridge's study that, at best, HRT fails to prevent the structural changes to the brain that leave women more vulnerable than men to cognitive decline. At its worst, it can exacerbate certain issues. This revelation makes lifestyle interventions even more critical as the only reliable defense against diseases like Alzheimer's later in life.

It is evident from the University of Cambridge's study that, at best, HRT fails to prevent the structural changes to the brain that leave women more vulnerable than men to cognitive decline. At its worst, it can exacerbate certain issues. This revelation makes lifestyle interventions even more critical as the only reliable defense against diseases like Alzheimer's later in life.

There is a 48% chance that a partial reprogramming-based therapy will receive regulatory approval for treating Alzheimer’s disease before January 1, 2035, according to the Metaculus prediction community.

There is a 48% chance that a partial reprogramming-based therapy will receive regulatory approval for treating Alzheimer’s disease before January 1, 2035, according to the Metaculus prediction community.

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Menopause Linked to Brain Grey Matter Loss, Study Finds

Health

Women's health

Healthcare

It's evident from the University of Cambridge's study that, at best, HRT fails to prevent the structural changes to the brain that leave women more vulnerable than men to cognitive decline. At its worst, it can exacerbate certain issues. This revelation makes lifestyle interventions even more critical as the only reliable defense against diseases like Alzheimer's later in life. More research is needed on the HRT variable.

It's evident from the University of Cambridge's study that, at best, HRT fails to prevent the structural changes to the brain that leave women more vulnerable than men to cognitive decline. At its worst, it can exacerbate certain issues. This revelation makes lifestyle interventions even more critical as the only reliable defense against diseases like Alzheimer's later in life. More research is needed on the HRT variable.

Study: Menopause Linked to Brain Gray Matter Loss

Study: Menopause Linked to Brain GreyGray Matter Loss, Study Finds

The Spin

Metaculus Prediction

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