Fertility Sterility

A 3D HUMAN BLASTOID AND ENDOMETRIAL MODEL FOR STUDYING HUMAN IMPLANTATION AND IMPLANTATION FAILURES

Scientists learn more about how human embryos implant using artificial wombs

Cell Press

Modeling human embryo implantation in vitro

Mirage News

Scientists Eavesdrop on Embryo-Mother Implantation Talks

Guardian

Scientists create replica human womb lining and implant early-stage embryos

MIT Technology Review

Researchers are getting organoids pregnant with human embryos

Medicalxpress

System replicates womb lining to 'listen in' to embryo-mother interactions during implantation

The New York Times

Opinion | Human Embryo Research: What Time Limit Should We Set?

A 3D in vitro model for studying human implantation and implantation failure

leo_jwu

Oxford Academic

7704144

Metaculus

Massive Multiple Embryo Selection

Researchers at the Babraham Institute and Stanford University developed a three-dimensional model system that replicates the womb lining with high biological accuracy, using epithelial and stromal cells isolated from donated endometrial tissue. The model was tested with donated early-stage human embryos from IVF procedures.

Researchers at the Babraham Institute and Stanford University developed a three-dimensional model system that replicates the womb lining with high biological accuracy, using epithelial and stromal cells isolated from donated endometrial tissue. The model was tested with donated early-stage human embryos from IVF procedures.

Scientists in Beijing and teams in the United Kingdom, Spain and the United States published three papers in Cell Press journals describing efforts to mimic the first moments of pregnancy in laboratory settings. The experiments combined human embryos from IVF centers with organoids made of endometrial cells.

Scientists in Beijing and teams in the United Kingdom, Spain and the United States published three papers in Cell Press journals describing efforts to mimic the first moments of pregnancy in laboratory settings. The experiments combined human embryos from IVF centers with organoids made of endometrial cells.

Following implantation in the laboratory models, embryos increased secretion of human chorionic gonadotropin, the biochemical marker used in pregnancy tests to confirm pregnancy. The systems supported post-implantation development, enabling analysis of embryo stages 12 to 14 days after fertilization.

Following implantation in the laboratory models, embryos increased secretion of human chorionic gonadotropin, the biochemical marker used in pregnancy tests to confirm pregnancy. The systems supported post-implantation development, enabling analysis of embryo stages 12 to 14 days after fertilization.

The high rate of implantation failure represents one of the main limiting factors for IVF success, with about half of all embryos failing to implant. The new models allow scientists to study interactions between the womb and embryo to look for causes behind implantation failure.

The high rate of implantation failure represents one of the main limiting factors for IVF success, with about half of all embryos failing to implant. The new models allow scientists to study interactions between the womb and embryo to look for causes behind implantation failure.

The Beijing team tested approximately 50 donated IVF embryos and ran about 1,000 experiments using blastoids, which are mimics of early-stage human embryos manufactured from stem cells. They screened 1,119 approved drugs to identify compounds that might improve implantation rates in patients.

The Beijing team tested approximately 50 donated IVF embryos and ran about 1,000 experiments using blastoids, which are mimics of early-stage human embryos manufactured from stem cells. They screened 1,119 approved drugs to identify compounds that might improve implantation rates in patients.

All experiments were stopped when embryos were two weeks old or sooner, adhering to legal and ethical rules that typically restrict scientists from going further than 14 days. The research raises questions about using these devices to study human embryos past the 14-day limit.

All experiments were stopped when embryos were two weeks old or sooner, adhering to legal and ethical rules that typically restrict scientists from going further than 14 days. The research raises questions about using these devices to study human embryos past the 14-day limit.

Fertility Sterility #

NPR #

Cell Press #

Mirage News #

Guardian #

MIT Technology Review #

Medicalxpress #

The New York Times #35285

Oxford Academic #

Metaculus #

Scientists create replica human womb lining and implant early-stage embryos

Abortion

Science & technology

Women

Scientists Create Lab Model of Womb to Study Implantation

Scientists Create Lab Model of Womb to Study Implantation

Scientists createCreate replicaLab humanModel wombof liningWomb andto implantStudy early-stage embryosImplantation

Articles on this story

Sign Up for Our Free Newsletters
Sign Up for Our Free Newsletters

Scientists Create Lab Model of Womb to Study Implantation

Scientists createCreate replicaLab humanModel wombof liningWomb andto implantStudy early-stage embryosImplantation

Articles on this story

Sign Up for Our Free NewslettersSign Up for Our Free Newsletters

Sign Up for Our Free Newsletters
Sign Up for Our Free Newsletters