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The World Health Organization (WHO) on Monday released its first guidelines on the use of Glucagon-Like Peptide-1 (GLP-1) therapies for treating obesity, a disease affecting more than 1 billion people globally, which the WHO projects will double by 2030, “without decisive action.”

The World Health Organization (WHO) on Monday released its first guidelines on the use of Glucagon-Like Peptide-1 (GLP-1) therapies for treating obesity, a disease affecting more than 1 billion people globally, which the WHO projects will double by 2030, “without decisive action.”

Published in the JAMA medical journal, the WHO issued two recommendations, the first of which approved the use of GLP-1 therapies, including semaglutide, liraglutide and tirzepatide, for the long-term treatment of obesity in adults, excluding pregnant women.

Published in the JAMA medical journal, the WHO issued two recommendations, the first of which approved the use of GLP-1 therapies, including semaglutide, liraglutide and tirzepatide, for the long-term treatment of obesity in adults, excluding pregnant women.

For its second recommendation, the UN organization advised that GLP-1 therapies be combined with intensive behavioral therapy (IBT), which includes a healthy diet and physical exercise, to “amplify and sustain the therapeutic benefits of the medication.”

For its second recommendation, the UN organization advised that GLP-1 therapies be combined with intensive behavioral therapy (IBT), which includes a healthy diet and physical exercise, to “amplify and sustain the therapeutic benefits of the medication.”

Both recommendations were conditional, with the WHO citing limited data on the long-term effects of GLP-1 therapies and “low certainty evidence” that IBT would enhance their performance, as well as the cost of the treatment and the unpreparedness of health care systems to offer it.

Both recommendations were conditional, with the WHO citing limited data on the long-term effects of GLP-1 therapies and “low certainty evidence” that IBT would enhance their performance, as well as the cost of the treatment and the unpreparedness of health care systems to offer it.

The WHO further recommended strategies to establish “widespread and fair access” to GLP-1 therapies — such as pooled procurement and tiered pricing — given its projection that current GLP-1 production levels will cover fewer than 10% of those already living with obesity by 2030.

The WHO further recommended strategies to establish “widespread and fair access” to GLP-1 therapies — such as pooled procurement and tiered pricing — given its projection that current GLP-1 production levels will cover fewer than 10% of those already living with obesity by 2030.

The guidance is the latest in the WHO’s promotion of the weight loss drugs, following the organization’s addition of GLP-1 therapies to its Essential Medicines List for managing type 2 diabetes in high-risk groups in September.

The guidance is the latest in the WHO’s promotion of the weight loss drugs, following the organization’s addition of GLP-1 therapies to its Essential Medicines List for managing type 2 diabetes in high-risk groups in September.

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The World Health Organization (WHO) released its first guidelines on the use of Glucagon-Like Peptide-1 (GLP-1) therapies for treating obesity, a disease affecting more than 1 billion people globally, which the WHO projects will double by 2030, “without decisive action.”

The World Health Organization (WHO) released its first guidelines on the use of Glucagon-Like Peptide-1 (GLP-1) therapies for treating obesity, a disease affecting more than 1 billion people globally, which the WHO projects will double by 2030, “without decisive action.”

Weight loss drugs fail to address the real problem and create dangerous dependencies. These medications fail to teach healthier eating habits and come with serious side effects like nausea and depression, with patients typically regaining weight after ending treatment. Weight loss drugs, therefore, ignore the root causes of obesity in favor of temporarily treating the symptoms.

Weight loss drugs fail to address the real problem and create dangerous dependencies. These medications fail to teach healthier eating habits and come with serious side effects like nausea and depression, with patients typically regaining weight after ending treatment. Weight loss drugs, therefore, ignore the root causes of obesity in favor of temporarily treating the symptoms.

GLP-1 therapies represent a significant breakthrough in treating obesity, offering an effective form of treatment that extends beyond weight loss to other complications, like diabetes. As part of a comprehensive approach to care, these drugs could revolutionize health outcomes for millions, which is why it is essential to ensure universal access to these therapies as soon as possible.

GLP-1 therapies represent a significant breakthrough in treating obesity, offering an effective form of treatment that extends beyond weight loss to other complications, like diabetes. As part of a comprehensive approach to care, these drugs could revolutionize health outcomes for millions, which is why it is essential to ensure universal access to these therapies as soon as possible.

There is a 74% chance that a small molecule GLP-1-based drug will be approved for the treatment of obesity by the FDA or EMA by 2029, according to the Metaculus prediction community.

There is a 74% chance that a small molecule GLP-1-based drug will be approved for the treatment of obesity by the FDA or EMA by 2029, according to the Metaculus prediction community.

Peter Dazeley/Getty Images

Peter Dazeley/Getty Images

WHO Issues First Guidelines for GLP-1 Obesity Treatments

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Weight loss drugs fail to address the real problem of obesity and create dangerous dependencies. These medications fail to teach healthier eating habits and come with serious side effects like nausea and depression, with patients typically regaining weight after ending treatment. Weight loss drugs, therefore, ignore the root causes of obesity in favor of temporarily treating the symptoms.

Weight loss drugs fail to address the real problem of obesity and create dangerous dependencies. These medications fail to teach healthier eating habits and come with serious side effects like nausea and depression, with patients typically regaining weight after ending treatment. Weight loss drugs, therefore, ignore the root causes of obesity in favor of temporarily treating the symptoms.

WHO Issues First Guidelines for GLP-1 Obesity Treatments

WHO Issues First Guidelines for GLP-1 Obesity Treatments

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WHO Issues First Guidelines for GLP-1 Obesity Treatments

WHO Issues First Guidelines for GLP-1 Obesity Treatments

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