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Novo Nordisk Shares Plunge as Alzheimer's Drug Trials Fail

Novo Nordisk Shares Plunge as Alzheimer's Drug Trials Fail

Novo Nordisk Shares Plunge as Alzheimer's Drug Trials Fail
Above: An Ozempic needle injection pen. Image credit: Jaap Arriens/NurPhoto/Getty Images

The Spin

Novo NordiskIt's Alzheimer'sa drugvery failurebad isday afor devastatingAlzheimer's blowtreatment thatresearch. wipedHopes $20had billionbeen fromhigh thefor companyJ&J's markettau-targeting valueantibody, inseen aby singlemany day.as Thea Danishpotential drugmakerbreakthrough desperatelyafter neededyears thisof winsetbacks afterin athe yearfield. ofIts slidingdisappointing sharesoutcome andunderscores slowinghow sales,difficult butit itsremains ownto executivesslow calledor ithalt athis "lotterycomplex ticket"disease. thatFor turnedpatients, outfamilies toand beclinicians, worthless.the Thisnews massiveis 10%another stockpainful plungereminder showsof investorsthe haveurgent lostneed confidencefor indrugs Novo'sthat abilitytruly tochange escape the quicksandcourse itof Alzheimer's stuck in.

TheNovo semaglutideNordisk's trialAlzheimer's drug failure actuallyis reinforcesa devastating blow that wiped $20 billion from the drugcompany's potentialmarket forvalue preventingin Alzheimer'sa beforesingle symptoms appearday. Real-worldThe dataDanish consistentlydrugmaker showdesperately peopleneeded onthis GLP-1win drugsafter havea loweryear dementiaof risksliding overshares manyand yearsslowing sales, whilebut theseits trialsown onlyexecutives lastedcalled twoit yearsa on"lottery patientsticket" withthat establishedturned diseaseout to be worthless. TheThis biomarkermassive improvements10% suggeststock thatplunge thisshows classinvestors ofhave drugslost couldconfidence reshapein theNovo's courseability ofto neurodegenerationescape whenthe usedquicksand earlierit's stuck in.

It'sThe asemaglutide verytrial badfailure dayactually forreinforces Alzheimerthe drug's treatmentpotential research.for Hopespreventing had been high for J&JAlzheimer's tau-targetingbefore antibody,symptoms seenappear. byReal-world manydata asconsistently ashow potentialpeople breakthroughon afterGLP-1 yearsdrugs ofhave setbackslower indementia therisk field.over Itsmany disappointingyears, outcomewhile underscoresthese howtrials difficultonly itlasted remainstwo toyears slowon orpatients haltwith thisestablished complex disease. ForThe patients,biomarker familiesimprovements andsuggest clinicians,that thethis newsclass is another painful reminder of the urgent need for drugs thatcould trulyreshape change the course of Alzheimer'sneurodegeneration when used earlier.

ThereIt's a 48%very chancebad thatday afor partialAlzheimer's reprogramming-basedtreatment therapyresearch. willHopes receivehad regulatorybeen approvalhigh for treating AlzheimerJ&J's diseasetau-targeting beforeantibody, Janseen by many as a potential breakthrough after years of setbacks in the field. 1Its disappointing outcome underscores how difficult it remains to slow or halt this complex disease. For patients, 2035families and clinicians, accordingthe tonews is another painful reminder of the Metaculusurgent predictionneed communityfor drugs that truly change the course of Alzheimer's.

Metaculus Prediction

There's a 48% chance that a partial reprogramming-based therapy will receive regulatory approval for treating Alzheimer's disease before Jan. 1, 2035, according to the Metaculus prediction community.


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© 2025 Improve the News Foundation. All rights reserved.Version 6.18.0

© 2025 Improve the News Foundation.

All rights reserved.

Version 6.18.0