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Researchers from King's College London have launched a clinical trial examining puberty blockers' impact on children with gender dysphoria, expecting to recruit 226 young people over three years with results anticipated in approximately four years.

Researchers from King's College London have launched a clinical trial examining puberty blockers' impact on children with gender dysphoria, expecting to recruit 226 young people over three years with results anticipated in approximately four years.

The trial follows the 2024 Cass Review, which concluded that research quality claiming benefits of puberty blockers for youngsters with gender dysphoria was poor, leading to a permanent NHS ban on prescribing these drugs to under-18s.

The trial follows the 2024 Cass Review, which concluded that research quality claiming benefits of puberty blockers for youngsters with gender dysphoria was poor, leading to a permanent NHS ban on prescribing these drugs to under-18s.

Participants will be divided into two groups — one receiving puberty blockers immediately for two years, another starting treatment after a one-year delay — with the youngest typically being 10-11 for girls and 11-12 for boys.

Participants will be divided into two groups — one receiving puberty blockers immediately for two years, another starting treatment after a one-year delay — with the youngest typically being 10-11 for girls and 11-12 for boys.

Children must have a diagnosis of gender incongruence for over two years, parental consent, and a persisting desire for treatment following psychological care to participate in the study led by Professor Emily Simonoff.

Children must have a diagnosis of gender incongruence for over two years, parental consent, and a persisting desire for treatment following psychological care to participate in the study led by Professor Emily Simonoff.

A companion study called Pathways Connect will examine brain development in approximately 250 young people, comparing those receiving puberty blockers with those accessing non-medical gender care through MRI imaging and cognitive tests.

A companion study called Pathways Connect will examine brain development in approximately 250 young people, comparing those receiving puberty blockers with those accessing non-medical gender care through MRI imaging and cognitive tests.

Some participants may continue taking puberty blockers after the trial ends if deemed clinically appropriate, despite the UK ban, while researchers monitor potential effects on bone health, fertility, and brain development throughout the study.

Some participants may continue taking puberty blockers after the trial ends if deemed clinically appropriate, despite the UK ban, while researchers monitor potential effects on bone health, fertility, and brain development throughout the study.

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