EurekAlert!

World's largest metabolomic study completed, paving way for predictive medicine

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Worlds Largest Metabolomic Study Completed Paving Way For Predictive Medicine

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Independent

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UK Biobank completed the world's largest metabolomic study by analyzing blood samples from 500,000 volunteers to measure nearly 250 different proteins, sugars, fats and other compounds, with Nightingale Health conducting 50,000 hours of analysis.

UK Biobank completed the world's largest metabolomic study by analyzing blood samples from 500,000 volunteers to measure nearly 250 different proteins, sugars, fats and other compounds, with Nightingale Health conducting 50,000 hours of analysis.

The metabolic profiles capture genetic predisposition and environmental exposures including diet, exercise, pollution and stress, providing a comprehensive snapshot of a person's physiological state that is more dynamic than fixed genetic data.

The metabolic profiles capture genetic predisposition and environmental exposures including diet, exercise, pollution and stress, providing a comprehensive snapshot of a person's physiological state that is more dynamic than fixed genetic data.

When organs malfunction, metabolic profiles shift in predictable ways, with diseased livers driving up ammonia levels, damaged kidneys increasing urea and creatinine, muscle damage raising lactate, and cancer causing glucose uptake to surge.

When organs malfunction, metabolic profiles shift in predictable ways, with diseased livers driving up ammonia levels, damaged kidneys increasing urea and creatinine, muscle damage raising lactate, and cancer causing glucose uptake to surge.

Research using existing metabolomic data has already produced a blood test for Type 2 diabetes risk assessment that is currently used in clinical practice in Finland and Singapore, demonstrating practical applications of the technology.

Research using existing metabolomic data has already produced a blood test for Type 2 diabetes risk assessment that is currently used in clinical practice in Finland and Singapore, demonstrating practical applications of the technology.

Scientists can now predict disease risk 10 to 15 years in advance, allowing doctors to intervene early and help patients in their 40s make lifestyle changes when biomarkers indicate increased risk for their age group.

Scientists can now predict disease risk 10 to 15 years in advance, allowing doctors to intervene early and help patients in their 40s make lifestyle changes when biomarkers indicate increased risk for their age group.

The complete metabolomic dataset is now available to approved researchers worldwide through UK Biobank's Research Analysis Platform, enabling global scientific collaboration to advance understanding of blood biomarkers and human health.

The complete metabolomic dataset is now available to approved researchers worldwide through UK Biobank's Research Analysis Platform, enabling global scientific collaboration to advance understanding of blood biomarkers and human health.

UK Biobank Completes World's Largest Blood Study of 500K

UK Biobank Completes World's Largest Blood Study of 500K

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UK Biobank Completes World's Largest Blood Study of 500K

UK Biobank Completes World's Largest Blood Study of 500K

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