The INHANCE trial conducted at McGill University enrolled 92 community-dwelling healthy older adults aged 65 and above from July 2021 to December 2023, with final follow-up completed in June 2024, representing the largest FEOBV-PET study to date.</span

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IFLScience

The INHANCE trial conducted at McGill University enrolled 92 community-dwelling healthy older adults aged 65 and above from July 2021 to December 2023, with final follow-up completed in June 2024, representing the largest FEOBV-PET study to date.

Participants were randomly assigned to either speed-based cognitive training using BrainHQ exercises or an active control group playing nonspeeded computer games, with both groups completing 35 hours of training over 10 weeks at 30 minutes per day.</span

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Sciencedirect

Participants were randomly assigned to either speed-based cognitive training using BrainHQ exercises or an active control group playing nonspeeded computer games, with both groups completing 35 hours of training over 10 weeks at 30 minutes per day.

The study used FEOBV-PET imaging with a radioactive tracer that binds to vesicular acetylcholine transporter proteins found exclusively on cholinergic neurons, allowing researchers to measure cholinergic system health before and after training.</span

Longevity Technology

The study used FEOBV-PET imaging with a radioactive tracer that binds to vesicular acetylcholine transporter proteins found exclusively on cholinergic neurons, allowing researchers to measure cholinergic system health before and after training.

Speed training participants showed a significant 2.3% increase in FEOBV binding in the anterior cingulate cortex, while the control group showed no significant changes, with the improvement potentially offsetting a decade of typical age-related decline.</span

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Speed training participants showed a significant 2.3% increase in FEOBV binding in the anterior cingulate cortex, while the control group showed no significant changes, with the improvement potentially offsetting a decade of typical age-related decline.

The cholinergic system naturally declines by approximately 2.5% per decade between ages 20 and 80, and current pharmaceutical treatments like cholinesterase inhibitors can only prevent acetylcholine breakdown rather than increase production.</span

The cholinergic system naturally declines by approximately 2.5% per decade between ages 20 and 80, and current pharmaceutical treatments like cholinesterase inhibitors can only prevent acetylcholine breakdown rather than increase production.

This represents the first human study demonstrating that any intervention, pharmaceutical or behavioral, can restore cholinergic function to levels typically seen in someone 10 years younger, with implications for dementia prevention and cognitive health.</span

McGill University

This represents the first human study demonstrating that any intervention, pharmaceutical or behavioral, can restore cholinergic function to levels typically seen in someone 10 years younger, with implications for dementia prevention and cognitive health.

Brain Training Reverses 10 Years of Cognitive Aging

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Brain Training Reverses 10 Years of Cognitive Aging

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