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Development and validation of blood-based diagnostic biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch 3-dimensional genomic regulatory immuno-genetic profili

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'Breakthrough' blood test detects chronic fatigue in 92% of cases

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Researchers from the University of East Anglia and Oxford Biodynamics developed a blood test for chronic fatigue syndrome using EpiSwitch 3D genomics technology that analyzes DNA folding patterns in blood samples from 47 severe ME/CFS patients and 61 healthy controls.</span

Researchers from the University of East Anglia and Oxford Biodynamics developed a blood test for chronic fatigue syndrome using EpiSwitch 3D genomics technology that analyzes DNA folding patterns in blood samples from 47 severe ME/CFS patients and 61 healthy controls.

The test demonstrated 92% sensitivity in identifying ME/CFS cases and 98% specificity in ruling out negative cases, achieving an overall accuracy of 96% according to findings published in the Journal of Translational Medicine.</span

The test demonstrated 92% sensitivity in identifying ME/CFS cases and 98% specificity in ruling out negative cases, achieving an overall accuracy of 96% according to findings published in the Journal of Translational Medicine.

ME/CFS affects more than 400,000 people in the UK and is characterized by extreme fatigue not relieved by rest, with patients often going undiagnosed for years due to the absence of definitive diagnostic tests.</span

ME/CFS affects more than 400,000 people in the UK and is characterized by extreme fatigue not relieved by rest, with patients often going undiagnosed for years due to the absence of definitive diagnostic tests.

The test identifies epigenetic markers that change during a person's life rather than fixed genetic code, as chronic fatigue syndrome is not a genetic disease people are born with, according to Oxford Biodynamics scientists.</span

The test identifies epigenetic markers that change during a person's life rather than fixed genetic code, as chronic fatigue syndrome is not a genetic disease people are born with, according to Oxford Biodynamics scientists.

Medical experts expressed caution about the findings, stating the test requires validation in better-designed independent studies and would likely cost around £1,000 if approved for clinical use.</span

Medical experts expressed caution about the findings, stating the test requires validation in better-designed independent studies and would likely cost around £1,000 if approved for clinical use.

Researchers hope the breakthrough could pave the way for similar diagnostic tests for long COVID, as post-COVID syndrome represents one example of ME/CFS where symptoms are triggered by the COVID-19 virus.</span

Researchers hope the breakthrough could pave the way for similar diagnostic tests for long COVID, as post-COVID syndrome represents one example of ME/CFS where symptoms are triggered by the COVID-19 virus.

New Blood Test Shows 96% Accuracy in Diagnosing ME/CFS

ScientistsNew developBlood first-everTest bloodShows test96% toAccuracy diagnosein Diagnosing ME/CFS

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New Blood Test Shows 96% Accuracy in Diagnosing ME/CFS

ScientistsNew developBlood first-everTest bloodShows test96% toAccuracy diagnosein Diagnosing ME/CFS

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