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Trio Wins Nobel Prize In Medicine For Discoveries On Immune System 0B566E73

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi received the 2025 Nobel Prize in Physiology or Medicine for their discoveries concerning peripheral immune tolerance, which prevents the immune system from attacking the body's own tissues.</span

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi received the 2025 Nobel Prize in Physiology or Medicine for their discoveries concerning peripheral immune tolerance, which prevents the immune system from attacking the body's own tissues.

Sakaguchi discovered regulatory T cells in 1995, while Brunkow and Ramsdell identified the Foxp3 gene mutation in 2001, with Sakaguchi later linking these findings to show how the gene controls regulatory T cell development.</span

Sakaguchi discovered regulatory T cells in 1995, while Brunkow and Ramsdell identified the Foxp3 gene mutation in 2001, with Sakaguchi later linking these findings to show how the gene controls regulatory T cell development.

The three laureates' research launched the field of peripheral tolerance and spurred development of medical treatments for cancer and autoimmune diseases, with more than 200 clinical trials currently investigating such therapies.</span

The three laureates' research launched the field of peripheral tolerance and spurred development of medical treatments for cancer and autoimmune diseases, with more than 200 clinical trials currently investigating such therapies.

Brunkow serves as a senior program manager at the Institute for Systems Biology in Seattle, Ramsdell works as a scientific adviser for Sonoma Biotherapeutics in San Francisco, and Sakaguchi is a distinguished professor at Osaka University.</span

Brunkow serves as a senior program manager at the Institute for Systems Biology in Seattle, Ramsdell works as a scientific adviser for Sonoma Biotherapeutics in San Francisco, and Sakaguchi is a distinguished professor at Osaka University.

The regulatory T cells function as security guards that suppress overreactive immune responses, helping explain why most people do not develop serious autoimmune diseases like type 1 diabetes or rheumatoid arthritis.</span

The regulatory T cells function as security guards that suppress overreactive immune responses, helping explain why most people do not develop serious autoimmune diseases like type 1 diabetes or rheumatoid arthritis.

The trio will share the prize money of 11 million Swedish kronor, approximately $1.2 million, with the award ceremony scheduled for December 10, the anniversary of Alfred Nobel's death.</span

The trio will share the prize money of 11 million Swedish kronor, approximately $1.2 million, with the award ceremony scheduled for December 10, the anniversary of Alfred Nobel's death.

Three Scientists Win 2025 Nobel Prize for Immune Research

Three Scientists Win 2025 Nobel Prize for medicineImmune Research

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Three Scientists Win 2025 Nobel Prize for Immune Research

Three Scientists Win 2025 Nobel Prize for medicineImmune Research

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