New Scientist

Autism may have subtypes that are genetically distinct from each other

Guardian

Autism should not be seen as single condition with one cause, say scientists

Different forms of autism may exist, not only different severities, genetic study shows

Metaculus

<h2>Editor's Note</h2>

An international study has found that children diagnosed with autism before age six typically show behavioral difficulties from early childhood, while those diagnosed after age 10 experience increasing social difficulties during adolescence.

Neuroscience News

An international study has found that children diagnosed with autism before age six typically show behavioral difficulties from early childhood, while those diagnosed after age 10 experience increasing social difficulties during adolescence.

Researchers analyzed genetic data from over 45,000 autistic individuals across Europe and the U.S., finding that the genetic profiles of early-diagnosed and later-diagnosed autism differ significantly, challenging the assumption that autism is a single unified condition with one underlying cause.

Medicalxpress

Researchers analyzed genetic data from over 45,000 autistic individuals across Europe and the U.S., finding that the genetic profiles of early-diagnosed and later-diagnosed autism differ significantly, challenging the assumption that autism is a single unified condition with one underlying cause.

The study, published Wednesday in Nature, revealed that commonly heritable polygenic factors explain approximately 11% of the variation in age at autism diagnosis, similar to the contribution of sociodemographic and clinical factors, which typically account for less than 15% of this variance.

Genetic Engineering & Biotechnology News

Nature

The study, published Wednesday in Nature, revealed that commonly heritable polygenic factors explain approximately 11% of the variation in age at autism diagnosis, similar to the contribution of sociodemographic and clinical factors, which typically account for less than 15% of this variance.

Later-diagnosed individuals showed increased likelihood of mental health conditions such as depression. Genetic analysis revealed stronger overlap between later-diagnosed autism and psychiatric disorders, including ADHD, depression and PTSD, than with early childhood autism.

Firstpost

Later-diagnosed individuals showed increased likelihood of mental health conditions such as depression. Genetic analysis revealed stronger overlap between later-diagnosed autism and psychiatric disorders, including ADHD, depression and PTSD, than with early childhood autism.

The research team used behavioral data from four birth cohorts, comprising 89 to 188 participants and applied the Strengths and Difficulties Questionnaire to track socioemotional and behavioral trajectories across childhood and adolescence in multiple countries.

Science Media Centre España

The research team used behavioral data from four birth cohorts, comprising 89 to 188 participants and applied the Strengths and Difficulties Questionnaire to track socioemotional and behavioral trajectories across childhood and adolescence in multiple countries.

Scientists emphasized that these findings highlight average differences on a gradient rather than distinct diagnostic categories, noting that many individuals fall somewhere between the early and later diagnosis patterns identified in the research.

Bioengineer.org

Scientists emphasized that these findings highlight average differences on a gradient rather than distinct diagnostic categories, noting that many individuals fall somewhere between the early and later diagnosis patterns identified in the research.

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This research proves autism isn't one condition but multiple distinct disorders with different genetic foundations. Children follow separate developmental paths — some struggle early while others face difficulties later in adolescence. This discovery will revolutionize the diagnosis and treatment of diseases.

This research proves autism isn't one condition but multiple distinct disorders with different genetic foundations. Children follow separate developmental paths — some struggle early while others face difficulties later in adolescence. This discovery will revolutionize the diagnosis and treatment of diseases.

New Scientist #4005

Late-diagnosed autism isn't milder — it's genetically similar to depression and ADHD, creating years of undiagnosed suffering. Without early support, these kids get bullied and develop mental health issues from trying to fit in. The focus should be on helping autistic people thrive.

Late-diagnosed autism isn't milder — it's genetically similar to depression and ADHD, creating years of undiagnosed suffering. Without early support, these kids get bullied and develop mental health issues from trying to fit in. The focus should be on helping autistic people thrive.

NBC #7699

There's a 15% chance that any HHS study will claim to show evidence of a link between vaccines and autism before Jan. 21, 2029, according to the Metaculus prediction community.

There's a 15% chance that any HHS study will claim to show evidence of a link between vaccines and autism before Jan. 21, 2029, according to the Metaculus prediction community.

Metaculus #

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Study Finds Different Genetic Profiles in Early vs Late Autism

Diseases & conditions

Health

This groundbreaking study reveals that early-childhood autism stems from distinct genetic profiles compared to late-diagnosed cases, challenging the one-size-fits-all model. This genetic divergence explains varied developmental paths, paving the way for precision medicine—personalized therapies that target specific subtypes for better outcomes. Families now have hope for earlier, more effective support.

This groundbreaking study reveals that early-childhood autism stems from distinct genetic profiles compared to late-diagnosed cases, challenging the one-size-fits-all model. This genetic divergence explains varied developmental paths, paving the way for precision medicine—personalized therapies that target specific subtypes for better outcomes. Families now have hope for earlier, more effective support.

Early- and late-diagnosed autism are genetically distinct

While the study claims separate genetic tracks for early versus late autism, it overlooks environmental factors and overlaps in symptoms. Labeling subtypes prematurely could stigmatize late-diagnosed individuals or divert resources from holistic care, ignoring autism's spectrum nature. More longitudinal data is essential before reshaping diagnostics.

While the study claims separate genetic tracks for early versus late autism, it overlooks environmental factors and overlaps in symptoms. Labeling subtypes prematurely could stigmatize late-diagnosed individuals or divert resources from holistic care, ignoring autism's spectrum nature. More longitudinal data is essential before reshaping diagnostics.

Study Finds Different Genetic Profiles in Early vs Late Autism

Study Finds Different Genetic Profiles in Early vs Late Autism

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Study Finds Different Genetic Profiles in Early vs Late Autism

Study Finds Different Genetic Profiles in Early vs Late Autism

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