New Scientist

Autism may have subtypes that are genetically distinct from each other

Guardian

Autism should not be seen as single condition with one cause, say scientists

Different forms of autism may exist, not only different severities, genetic study shows

Metaculus

<h2>Editor's Note</h2>

An international study, which analyzed genetic data from over 45,000 autistic individuals across Europe and the U.S., has found that children diagnosed with autism before age six typically show behavioral difficulties from early childhood, while those diagnosed after age 10 experience increasing social difficulties during adolescence.

Neuroscience News

An international study, which analyzed genetic data from over 45,000 autistic individuals across Europe and the U.S., has found that children diagnosed with autism before age six typically show behavioral difficulties from early childhood, while those diagnosed after age 10 experience increasing social difficulties during adolescence.

Researchers discovered that the genetic profiles of early-diagnosed and later-diagnosed autism differ significantly, with only modest overlap between the two groups, challenging the assumption that autism is a single unified condition with one underlying cause.

Medicalxpress

Researchers discovered that the genetic profiles of early-diagnosed and later-diagnosed autism differ significantly, with only modest overlap between the two groups, challenging the assumption that autism is a single unified condition with one underlying cause.

The study, published Wednesday in Nature, revealed that commonly heritable polygenic factors explain approximately 11% of the variation in age at autism diagnosis, similar to the contribution of sociodemographic and clinical factors, which typically account for less than 15% of this variance.

Genetic Engineering & Biotechnology News

Nature

The study, published Wednesday in Nature, revealed that commonly heritable polygenic factors explain approximately 11% of the variation in age at autism diagnosis, similar to the contribution of sociodemographic and clinical factors, which typically account for less than 15% of this variance.

Later-diagnosed individuals showed increased likelihood of mental health conditions such as depression. Genetic analysis revealed stronger overlap between later-diagnosed autism and psychiatric disorders, including ADHD, depression and PTSD, than with early childhood autism.

Firstpost

Later-diagnosed individuals showed increased likelihood of mental health conditions such as depression. Genetic analysis revealed stronger overlap between later-diagnosed autism and psychiatric disorders, including ADHD, depression and PTSD, than with early childhood autism.

The research team used behavioral data from four birth cohorts, comprising 89 to 188 participants and applied the Strengths and Difficulties Questionnaire to track socioemotional and behavioral trajectories across childhood and adolescence in multiple countries.

Science Media Centre España

The research team used behavioral data from four birth cohorts, comprising 89 to 188 participants and applied the Strengths and Difficulties Questionnaire to track socioemotional and behavioral trajectories across childhood and adolescence in multiple countries.

Scientists emphasized that these findings highlight average differences on a gradient rather than distinct diagnostic categories, noting that many individuals fall somewhere between the early and later diagnosis patterns identified in the research.

Bioengineer.org

Scientists emphasized that these findings highlight average differences on a gradient rather than distinct diagnostic categories, noting that many individuals fall somewhere between the early and later diagnosis patterns identified in the research.

New Scientist #1

Guardian #1

NBC #1

Metaculus #0

An international study analyzing genetic data from over 45,000 autistic individuals across Europe and the US found that children diagnosed with autism before age six typically show behavioral difficulties from early childhood, while those diagnosed after age 10 experience increasing social difficulties during adolescence.</span

Neuroscience News #

Guardian #3641

An international study analyzing genetic data from over 45,000 autistic individuals across Europe and the US found that children diagnosed with autism before age six typically show behavioral difficulties from early childhood, while those diagnosed after age 10 experience increasing social difficulties during adolescence.

Researchers discovered that the genetic profiles of early-diagnosed and later-diagnosed autism differ significantly, with only modest overlap between the two groups, challenging the assumption that autism represents a single unified condition with one underlying cause.</span

Medicalxpress #

Researchers discovered that the genetic profiles of early-diagnosed and later-diagnosed autism differ significantly, with only modest overlap between the two groups, challenging the assumption that autism represents a single unified condition with one underlying cause.

The study revealed that commonly heritable polygenic factors explain approximately 11% of the variation in age at autism diagnosis, similar to the contribution of sociodemographic and clinical factors which typically account for less than 15% of this variance.</span

Genetic Engineering & Biotechnology News #

Nature #

The study revealed that commonly heritable polygenic factors explain approximately 11% of the variation in age at autism diagnosis, similar to the contribution of sociodemographic and clinical factors which typically account for less than 15% of this variance.

Later-diagnosed individuals showed increased likelihood of mental health conditions such as depression, with genetic analysis revealing stronger overlap between later-diagnosed autism and psychiatric disorders including ADHD, depression and PTSD than with early childhood autism.</span

Firstpost #

Later-diagnosed individuals showed increased likelihood of mental health conditions such as depression, with genetic analysis revealing stronger overlap between later-diagnosed autism and psychiatric disorders including ADHD, depression and PTSD than with early childhood autism.

The research team used behavioral data from four birth cohorts ranging from 89 to 188 participants and applied the Strengths and Difficulties Questionnaire to track socioemotional and behavioral trajectories across childhood and adolescence in multiple countries.</span

Science Media Centre España #

The research team used behavioral data from four birth cohorts ranging from 89 to 188 participants and applied the Strengths and Difficulties Questionnaire to track socioemotional and behavioral trajectories across childhood and adolescence in multiple countries.

Scientists emphasized that these findings represent average differences on a gradient rather than distinct diagnostic categories, noting that many individuals fall somewhere between the early and later diagnosis patterns identified in the research.</span

Bioengineer.org #

Scientists emphasized that these findings represent average differences on a gradient rather than distinct diagnostic categories, noting that many individuals fall somewhere between the early and later diagnosis patterns identified in the research.

New research proves autism isn't one condition but multiple distinct disorders with different genetic foundations. Children follow separate developmental paths — some struggle early while others face difficulties later in adolescence. This groundbreaking discovery will revolutionize diagnosis and treatment.

New research proves autism isn't one condition but multiple distinct disorders with different genetic foundations. Children follow separate developmental paths — some struggle early while others face difficulties later in adolescence. This groundbreaking discovery will revolutionize diagnosis and treatment.</span

New Scientist #4005

Late-diagnosed autism isn't milder — it's genetically similar to depression and ADHD, creating years of undiagnosed suffering. Without early support, these kids get bullied and develop mental health issues from trying to fit in. The focus should be helping autistic people thrive.

Late-diagnosed autism isn't milder — it's genetically similar to depression and ADHD, creating years of undiagnosed suffering. Without early support, these kids get bullied and develop mental health issues from trying to fit in. The focus should be helping autistic people thrive.</span

NBC #7699

Study Reveals Different Genetic Profiles in Early vs Late Autism

Diseases & conditions

Health

This research proves autism isn't one condition but multiple distinct disorders with different genetic foundations. Children follow separate developmental paths — some struggle early while others face difficulties later in adolescence. This discovery will revolutionize the diagnosis and treatment of diseases.

This research proves autism isn't one condition but multiple distinct disorders with different genetic foundations. Children follow separate developmental paths — some struggle early while others face difficulties later in adolescence. This discovery will revolutionize the diagnosis and treatment of diseases.

Late-diagnosed autism isn't milder — it's genetically similar to depression and ADHD, creating years of undiagnosed suffering. Without early support, these kids get bullied and develop mental health issues from trying to fit in. The focus should be on helping autistic people thrive.

Late-diagnosed autism isn't milder — it's genetically similar to depression and ADHD, creating years of undiagnosed suffering. Without early support, these kids get bullied and develop mental health issues from trying to fit in. The focus should be on helping autistic people thrive.

There's a 15% chance that any HHS study will claim to show evidence of a link between vaccines and autism before Jan. 21, 2029, according to the Metaculus prediction community.

There's a 15% chance that any HHS study will claim to show evidence of a link between vaccines and autism before Jan. 21, 2029, according to the Metaculus prediction community.

Study Finds Different Genetic Profiles in Early vs Late Autism

Study RevealsFinds Different Genetic Profiles in Early vs Late Autism

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Metaculus Prediction

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