New Scientist

Egg cells made with DNA from human skin fertilised in the lab

Wired

Scientists Made Human Eggs from Skin Cells and Used Them to Form Embryos

Guardian

Human skin cells are turned into eggs in fertility breakthrough

Daily Mail

Huge fertility breakthrough as scientists create functional eggs from human SKIN cells: 'A step towards helping many women have their own genetic children'

Scientists use human skin cells to create functional eggs

Metaculus

First Birth from Stem-Cell Gametes

Jack Tseng

Eriona Hysolli

Colossal Biosciences Inc.

Beth Shapiro

Joseph Frederickson

Ben Lamm

Brian Klaas

George Church

Ben Mezrich

Mary Beth Griggs

Jeremy Austin

"[N]o one is actually going to bring mammoths back."

"Is this [the restoration of woolly mammoths] going to happen anytime soon? The answer is absolutely not."

"Mammoth de-extinction is more about media attention for the scientists and less about doing serious science."

"It feels to me that a mammoth is a long way in the future."

"I think it's [bringing back woolly mammoth] definitely within the technology."

"In 2028, if all goes according to plan, a six-foot-five narcoleptic scientist with a bushy white beard will resurrect the first living woolly mammoth in 4,000 years."

"I think the first engineered elephant will be the major milestone and that may be consistent with Ben's (Lamm) prediction of six years from 2021."

"That timeline [2028 for the birth of the first mammoth calves] hasn't changed."

"We have set a date of late 2028 for our first mammoth and we are on track."

Will the Woolly Mammoth Be Resurrected by 2028?

Scientists at Oregon Health &amp; Science University have successfully created 82 functional human eggs from skin cells using a process called somatic cell nuclear transfer, in which the nucleus from skin cells was transplanted into donor eggs with their own nuclei removed.

Scientists at Oregon Health & Science University have successfully created 82 functional human eggs from skin cells using a process called somatic cell nuclear transfer, in which the nucleus from skin cells was transplanted into donor eggs with their own nuclei removed.

The research team developed a technique called mitomeiosis to address the chromosome problem, using chemical treatment with roscovitine to induce the eggs to discard half their chromosomes, reducing them from 46 to the required 23.

Science News

New York Post

The research team developed a technique called mitomeiosis to address the chromosome problem, using chemical treatment with roscovitine to induce the eggs to discard half their chromosomes, reducing them from 46 to the required 23.

The study, published in the journal Nature Communications on Tuesday, found that approximately 9% of the created eggs progressed to the blastocyst stage of embryo development after fertilization, equivalent to five or six days post-fertilization, when embryos are typically transferred during IVF treatment.

Fox 59

The study, published in the journal Nature Communications on Tuesday, found that approximately 9% of the created eggs progressed to the blastocyst stage of embryo development after fertilization, equivalent to five or six days post-fertilization, when embryos are typically transferred during IVF treatment.

All resulting embryos contained chromosomal abnormalities, with some having 48 chromosomes instead of the normal 46, and chromosomes pairing randomly rather than with their specific counterparts, as occurs in natural meiosis.

BBC News

The Times

All resulting embryos contained chromosomal abnormalities, with some having 48 chromosomes instead of the normal 46, and chromosomes pairing randomly rather than with their specific counterparts, as occurs in natural meiosis.

According to the lead author, Prof Shoukhrat Mitalipov, the technique could potentially benefit "women of advanced maternal age," same-sex couples and women "who have been through chemotherapy."

telegraph.co.uk

According to the lead author, Prof Shoukhrat Mitalipov, the technique could potentially benefit "women of advanced maternal age," same-sex couples and women "who have been through chemotherapy."

Researchers estimate that at least a decade of additional research is needed to perfect the technique and address safety concerns before clinical trials could begin, with regulatory barriers expected due to the cloning-associated methodology.

OHSU News

Researchers estimate that at least a decade of additional research is needed to perfect the technique and address safety concerns before clinical trials could begin, with regulatory barriers expected due to the cloning-associated methodology.

New Scientist #1

Wired #1

Guardian #1

Daily Mail #1

CNN #0

Metaculus #0

Scientists at Oregon Health & Science University successfully created 82 functional human eggs from skin cells using a process called somatic cell nuclear transfer, where the nucleus from skin cells was transplanted into donor eggs with their nuclei removed.</span

Guardian #4575

Daily Mail #4919

Scientists at Oregon Health & Science University successfully created 82 functional human eggs from skin cells using a process called somatic cell nuclear transfer, where the nucleus from skin cells was transplanted into donor eggs with their nuclei removed.

The research team developed a technique called mitomeiosis to address the chromosome problem, using chemical treatment with roscovitine to induce the eggs to discard half their chromosomes, reducing them from 46 to the required 23.</span

CNN #

Science News #

Approximately 9% of the created eggs progressed to the blastocyst stage of embryo development after fertilization, equivalent to five or six days post-fertilization when embryos are typically transferred during IVF treatment.</span

Fox 59 #

Approximately 9% of the created eggs progressed to the blastocyst stage of embryo development after fertilization, equivalent to five or six days post-fertilization when embryos are typically transferred during IVF treatment.

All resulting embryos contained chromosomal abnormalities, with some having 48 chromosomes instead of 46, and chromosomes pairing randomly rather than with their specific counterparts as occurs in natural meiosis.</span

BBC News #

All resulting embryos contained chromosomal abnormalities, with some having 48 chromosomes instead of 46, and chromosomes pairing randomly rather than with their specific counterparts as occurs in natural meiosis.

The technique could potentially benefit women who lost their eggs due to cancer treatment or advanced age, and could allow same-sex male couples to have children genetically related to both partners using male skin cells.</span

telegraph.co.uk #

The technique could potentially benefit women who lost their eggs due to cancer treatment or advanced age, and could allow same-sex male couples to have children genetically related to both partners using male skin cells.

Researchers estimate at least a decade of additional research is needed to perfect the technique and address safety concerns before clinical trials could begin, with regulatory barriers expected due to the cloning-associated methodology.</span

Researchers estimate at least a decade of additional research is needed to perfect the technique and address safety concerns before clinical trials could begin, with regulatory barriers expected due to the cloning-associated methodology.

Scientists achieved a groundbreaking fertility breakthrough by creating functional human eggs from skin cells that can be fertilized and develop into early embryos. This revolutionary technique could transform reproductive medicine by helping gay couples have genetically related children and offering hope to women with fertility problems or those who've lost eggs due to cancer treatment.

Scientists achieved a groundbreaking fertility breakthrough by creating functional human eggs from skin cells that can be fertilized and develop into early embryos. This revolutionary technique could transform reproductive medicine by helping gay couples have genetically related children and offering hope to women with fertility problems or those who've lost eggs due to cancer treatment.</span

Wired #3359

New Scientist #3791

This experimental technique remains dangerously premature with severe chromosomal defects plaguing all resulting embryos and success rates under 10 percent. The random chromosome segregation creates aneuploid embryos that would fail in the womb, making clinical application at least a decade away while significant safety challenges persist.

This experimental technique remains dangerously premature with severe chromosomal defects plaguing all resulting embryos and success rates under 10 percent. The random chromosome segregation creates aneuploid embryos that would fail in the womb, making clinical application at least a decade away while significant safety challenges persist.</span

Nature

Nature #

Induction of experimental cell division to generate cells with reduced chromosome ploidy

ScienceAlert

ScienceAlert #

Working Egg Cells Made Using DNA From Human Skin in World First

Scientists Create Human Eggs from Skin Cells in Breakthrough

Research

Science & technology

This experimental technique remains dangerously premature, with severe chromosomal defects plaguing all resulting embryos and success rates under 10 percent. The random chromosome segregation creates aneuploid embryos that would fail in the womb, making clinical application at least a decade away, while significant safety challenges persist.

This experimental technique remains dangerously premature, with severe chromosomal defects plaguing all resulting embryos and success rates under 10 percent. The random chromosome segregation creates aneuploid embryos that would fail in the womb, making clinical application at least a decade away, while significant safety challenges persist.

Scientists achieved a groundbreaking fertility breakthrough by creating functional human eggs from skin cells. This revolutionary technique could transform reproductive medicine by helping gay couples have genetically related children and offering hope to women with fertility problems or those who've lost eggs due to cancer treatment.

Scientists achieved a groundbreaking fertility breakthrough by creating functional human eggs from skin cells. This revolutionary technique could transform reproductive medicine by helping gay couples have genetically related children and offering hope to women with fertility problems or those who've lost eggs due to cancer treatment.

Scientists Create Human Eggs from Skin Cells for First Time

Scientists Create Human Eggs from Skin Cells infor BreakthroughFirst Time

The Spin

The Controversies

Griggs

Frederickson

Austin

Shapiro

Tseng

Klaas

Church

Hysolli

Lamm

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