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Superbugs could kill millions more and cost $2tn a year by 2050, models show

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Antibiotic-Resistant Infection Deaths x2 2026

<span>Global health costs for treating antimicrobial resistance could increase by $176 billion annually, while antibiotic-resistant bacteria were associated with almost $700 billion in hospital costs globally in 2019. Productivity losses exceeded $193 billion due to excess deaths associated with antibiotic resistance, with resistant infections roughly twice as expensive to treat as those responsive to antibiotics.</span

BMJ Global Health

Global health costs for treating antimicrobial resistance could increase by $176 billion annually, while antibiotic-resistant bacteria were associated with almost $700 billion in hospital costs globally in 2019. Productivity losses exceeded $193 billion due to excess deaths associated with antibiotic resistance, with resistant infections roughly twice as expensive to treat as those responsive to antibiotics.

<span>Low- and lower-middle-income countries bear the heaviest burden of antimicrobial resistance, with health care costs increasing by $66 billion currently and projected to rise to $159 billion under business-as-usual scenarios. If resistance rates increased at the rate of the bottom 15% of countries, AMR health costs would rise to $325 billion and the global economy would be $1.7 trillion smaller in 2050.</span

Cgdev

Low- and lower-middle-income countries bear the heaviest burden of antimicrobial resistance, with health care costs increasing by $66 billion currently and projected to rise to $159 billion under business-as-usual scenarios. If resistance rates increased at the rate of the bottom 15% of countries, AMR health costs would rise to $325 billion and the global economy would be $1.7 trillion smaller in 2050.

<span>Vaccines targeting antibiotic-resistant infections could prevent substantial economic losses, with 30% of hospital costs (around $200 billion) and 40% of productivity losses (almost $80 billion) potentially averted under hypothetical vaccine scenarios. Vaccines against S. aureus, E. coli and K. pneumoniae would avert the most hospital costs at $169 billion total and $44 billion in productivity losses globally.</span

Vaccines targeting antibiotic-resistant infections could prevent substantial economic losses, with 30% of hospital costs (around $200 billion) and 40% of productivity losses (almost $80 billion) potentially averted under hypothetical vaccine scenarios. Vaccines against S. aureus, E. coli and K. pneumoniae would avert the most hospital costs at $169 billion total and $44 billion in productivity losses globally.

<span>The UK government has eliminated funding for the $265 million Fleming Fund, which supports antimicrobial resistance surveillance in 25 countries across Africa and Asia, as part of aid budget cuts from 0.5% to 0.3% of gross national income. The US Congress approved $9 billion in cuts to foreign aid programs, with the Trump administration confirming these reductions amid broader international aid budget decreases.</span

Observer (NY)

The UK government has eliminated funding for the $265 million Fleming Fund, which supports antimicrobial resistance surveillance in 25 countries across Africa and Asia, as part of aid budget cuts from 0.5% to 0.3% of gross national income. The US Congress approved $9 billion in cuts to foreign aid programs, with the Trump administration confirming these reductions amid broader international aid budget decreases.

<span>Mathematical models studying AMR transmission primarily focus on high-income regions like Europe and North America where surveillance data are more accessible, despite Sub-Saharan Africa carrying the highest AMR burden. Key pathogens contributing to AMR-associated deaths include E. coli, S. aureus, and K. pneumoniae, with significant modeling gaps evident for community-acquired infections and secondary bacterial infections following viral infections.</span

BioMed Central

Mathematical models studying AMR transmission primarily focus on high-income regions like Europe and North America where surveillance data are more accessible, despite Sub-Saharan Africa carrying the highest AMR burden. Key pathogens contributing to AMR-associated deaths include E. coli, S. aureus, and K. pneumoniae, with significant modeling gaps evident for community-acquired infections and secondary bacterial infections following viral infections.

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Fiscal responsibility demands tough choices, and domestic priorities must come first during challenging economic times. The partnerships and expertise from programs like the Fleming Fund will continue even without direct funding, while countries can develop their own surveillance capabilities. Defense spending increases are essential for national security, and the private sector can step up to fill gaps in global health initiatives.

<span>Fiscal responsibility demands tough choices, and domestic priorities must come first during challenging economic times. The partnerships and expertise from programs like the Fleming Fund will continue even without direct funding, while countries can develop their own surveillance capabilities. Defense spending increases are essential for national security, and the private sector can step up to fill gaps in global health initiatives.</span>

Superbugs Could Cost Global Economy $2 Trillion by 2050

Superbugs couldCould killCost millionsGlobal moreEconomy and cost $2tn2 aTrillion year by 2050, models show

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Superbugs Could Cost Global Economy $2 Trillion by 2050

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