Atlantic

HIV’s Most Promising Breakthrough Has Taken a Hit

Guardian

Breakthrough in search for HIV cure leaves researchers ‘overwhelmed’

Independent

Major breakthrough in battle for HIV cure ‘previously thought impossible’

Metaculus

When will a vaccine for HIV be administered to 10 million people?

<span>The mRNA technology instructs infected cells to reveal the dormant HIV virus by encoding the HIV Tat protein, which activates viral transcription and forces the virus out of its latent state within white blood cells where it evades immune system detection and current drug treatments.</span

Pharmaphorum

The mRNA technology instructs infected cells to reveal the dormant HIV virus by encoding the HIV Tat protein, which activates viral transcription and forces the virus out of its latent state within white blood cells where it evades immune system detection and current drug treatments.

<span>In laboratory tests using cells from HIV patients, the Tat-LNP X treatment achieved a 112-fold increase in multiply-spliced HIV RNA transcripts and a 17.2-fold increase in HIV virion production, significantly exceeding results from standard mitogen treatments used to reverse HIV latency.</span

Euro Weekly News

Nature

In laboratory tests using cells from HIV patients, the Tat-LNP X treatment achieved a 112-fold increase in multiply-spliced HIV RNA transcripts and a 17.2-fold increase in HIV virion production, significantly exceeding results from standard mitogen treatments used to reverse HIV latency.

<span>The study was conducted entirely in laboratory settings using donated cells from HIV patients, and researchers emphasize that years of animal testing and human safety trials would be required before any clinical application, with many biomedical discoveries ultimately failing to reach clinical use.</span

The study was conducted entirely in laboratory settings using donated cells from HIV patients, and researchers emphasize that years of animal testing and human safety trials would be required before any clinical application, with many biomedical discoveries ultimately failing to reach clinical use.

<span>Nearly 40 million people globally live with HIV and must take lifelong antiretroviral medication to suppress the virus, with UNAIDS reporting one HIV-related death every minute in 2023, highlighting the urgent need for curative treatments beyond current suppressive therapies.</span

Nearly 40 million people globally live with HIV and must take lifelong antiretroviral medication to suppress the virus, with UNAIDS reporting one HIV-related death every minute in 2023, highlighting the urgent need for curative treatments beyond current suppressive therapies.

<span>The research team initially doubted their results because the improvement was so dramatic compared to previous attempts, with Dr. Paula Cevaal stating they had "never seen anything close to as good" in terms of revealing the virus, though she cautioned about the long path to clinical application.</span

The research team initially doubted their results because the improvement was so dramatic compared to previous attempts, with Dr. Paula Cevaal stating they had "never seen anything close to as good" in terms of revealing the virus, though she cautioned about the long path to clinical application.

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While promising, this research remains in early laboratory stages with significant hurdles ahead. Many biomedical discoveries fail to reach patients, and this approach still requires years of testing before human trials. The technology only reveals the virus but doesn't eliminate it, requiring additional therapies for a complete cure.

<span>While promising, this research remains in early laboratory stages with significant hurdles ahead. Many biomedical discoveries fail to reach patients, and this approach still requires years of testing before human trials. The technology only reveals the virus but doesn't eliminate it, requiring additional therapies for a complete cure.</span>

Scientists Use mRNA to Force HIV Out of Hiding in Cells

BreakthroughScientists inUse searchmRNA forto Force HIV cureOut leavesof researchersHiding ‘overwhelmed’in Cells

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Scientists Use mRNA to Force HIV Out of Hiding in Cells

BreakthroughScientists inUse searchmRNA forto Force HIV cureOut leavesof researchersHiding ‘overwhelmed’in Cells

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