Time

A Baby Receives the First Customized CRISPR Treatment

A Pennsylvania baby is the first to successfully receive personalized gene therapy

LiveNOW from FOX

Baby born with rare disorder thrives after getting personalized gene editing treatment

Breitbart

Gene editing helped a desperately ill baby thrive. Scientists say it could someday treat millions

Science

Gene Editing Therapy Made Just 6 Months Helps Baby Life Threatening Diseas

CBS News

Infant becomes world's first patient to undergo personalized gene-editing treatment

Nature

Worlds first personalized CRISPR therapy given to baby with genetic disease

MIT Technology Review

This baby boy was treated with the first personalized gene-editing drug

Pennmedicine

World's First Patient Treated with Personalized CRISPR Therapy

National Institutes of Health (NIH)

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

Metaculus

ChildrensPhila

Wired

A Baby Received a Custom Crispr Treatment in Record Time

Jack Tseng

Eriona Hysolli

Colossal Biosciences Inc.

Beth Shapiro

Joseph Frederickson

Ben Lamm

Brian Klaas

George Church

Ben Mezrich

Mary Beth Griggs

Jeremy Austin

"[N]o one is actually going to bring mammoths back."

"Is this [the restoration of woolly mammoths] going to happen anytime soon? The answer is absolutely not."

"Mammoth de-extinction is more about media attention for the scientists and less about doing serious science."

"It feels to me that a mammoth is a long way in the future."

"I think it's [bringing back woolly mammoth] definitely within the technology."

"In 2028, if all goes according to plan, a six-foot-five narcoleptic scientist with a bushy white beard will resurrect the first living woolly mammoth in 4,000 years."

"I think the first engineered elephant will be the major milestone and that may be consistent with Ben's (Lamm) prediction of six years from 2021."

"That timeline [2028 for the birth of the first mammoth calves] hasn't changed."

"We have set a date of late 2028 for our first mammoth and we are on track."

Will the Woolly Mammoth Be Resurrected by 2028?

<span>The medical team, led by Dr. Kiran Musunuru and Dr. Rebecca Ahrens-Nicklas, developed a customized base editing therapy within six months to correct KJ's specific genetic mutation that prevents his body from properly processing ammonia, which can be toxic to the brain.</span

Chop

The medical team, led by Dr. Kiran Musunuru and Dr. Rebecca Ahrens-Nicklas, developed a customized base editing therapy within six months to correct KJ's specific genetic mutation that prevents his body from properly processing ammonia, which can be toxic to the brain.

<span>The experimental treatment, delivered through lipid nanoparticles to KJ's liver cells, involved three doses administered between February and April 2025, making him the first patient to receive a personalized CRISPR therapy designed for a single individual.</span

New York Post

The experimental treatment, delivered through lipid nanoparticles to KJ's liver cells, involved three doses administered between February and April 2025, making him the first patient to receive a personalized CRISPR therapy designed for a single individual.

<span>Following the treatment, KJ has shown positive responses including improved protein tolerance, better recovery from common illnesses, and reduced medication needs, though researchers emphasize it's too early to determine the full extent of the therapy's effectiveness.</span

Following the treatment, KJ has shown positive responses including improved protein tolerance, better recovery from common illnesses, and reduced medication needs, though researchers emphasize it's too early to determine the full extent of the therapy's effectiveness.

<span>The cost of developing this custom treatment was comparable to a liver transplant procedure, which typically exceeds $800,000, suggesting potential economic viability for future personalized genetic treatments.</span

The cost of developing this custom treatment was comparable to a liver transplant procedure, which typically exceeds $800,000, suggesting potential economic viability for future personalized genetic treatments.

<span>The breakthrough represents a significant advancement in treating rare genetic disorders, potentially opening doors for millions of patients with rare conditions who have limited treatment options.</span

The breakthrough represents a significant advancement in treating rare genetic disorders, potentially opening doors for millions of patients with rare conditions who have limited treatment options.

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Baby Is Healed With World’s First Personalized Gene-Editing Treatment

Health

Science & technology

World

The experimental nature of this treatment raises significant concerns about long-term safety and efficacy. Without comprehensive long-term studies, the risks of unintended genetic changes remain unknown, and the high cost of personalized treatments could create accessibility barriers for many patients who need them.

<span>The experimental nature of this treatment raises significant concerns about long-term safety and efficacy. Without comprehensive long-term studies, the risks of unintended genetic changes remain unknown, and the high cost of personalized treatments could create accessibility barriers for many patients who need them.</span>

Baby Makes History with Custom CRISPR Gene Therapy Success

Baby Makes History with Custom CRISPR Gene Therapy Success

Baby IsMakes HealedHistory Withwith World’sCustom FirstCRISPR Personalized Gene-Editing TreatmentTherapy Success

The Spin

The Controversies

Griggs

Frederickson

Austin

Shapiro

Tseng

Klaas

Church

Hysolli

Lamm

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Baby Makes History with Custom CRISPR Gene Therapy Success

Baby IsMakes HealedHistory Withwith World’sCustom FirstCRISPR Personalized Gene-Editing TreatmentTherapy Success

The Spin

The Controversies

Griggs

Frederickson

Austin

Shapiro

Tseng

Klaas

Church

Hysolli

Lamm

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