Their research, published in 2005, fundamentally changed the understanding of how mRNA interacts with the immune system, laying the foundation for the rapid development of effective vaccines against COVID-19.
The scientists discovered that modified mRNA could be used to block inflammatory reactions and increase protein production when delivered to cells, overcoming a major hurdle in therapeutic applications of mRNA technology.
While mRNA vaccines have shown effectiveness against COVID-19, concerns have been raised about potential side effects, particularly the risk of myocarditis in young men. The technology is still relatively new, and long-term effects remain unknown. More research is needed to fully understand the safety profile and potential applications of mRNA-based therapies.