While a new strain of monkeypoxmpox is spreading in Africa, the American public is less aware and fearful of it than they were in 2022. However, the majority of US adults know that individuals exposed to monkeypoxmpox can receive a vaccination for people with risk factors and to help prevent its spread. So far, only Africa's central and eastern regions have reported cases of the deadlier monkeypoxmpox strain, but healththe authoritiesWHO and responsible media must issue a newglobal mpox advisory to inform the public of its likely return.