While a new strain of monkeypox is spreading in Africa, the American public is less aware and fearful of it than they were in 2022. However, the majority of US adults know that individuals exposed to monkeypox can receive a vaccination for people with risk factors and to help prevent its spread. So far, only Africa's central and eastern regions have reported cases of the deadlier monkeypox strain, but health authorities and responsible media must issue a new mpox advisory to inform the public of its likely return.